Journal article
Decreased NK cell FcRγ in HIV-1 infected individuals receiving combination antiretroviral therapy: A cross sectional study
E Leeansyah, J Zhou, G Paukovics, SR Lewin, SM Crowe, A Jaworowski
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2010
Abstract
Background: FcRγ is an immunoreceptor tyrosine-based activation motif (ITAM)-signalling protein essential for immunoreceptor signaling and monocyte, macrophage and NK cell function. Previous study from our laboratory showed that FcRγ is down-regulated in HIV-infected macrophages in vitro. FcRγ expression in immune cells present in HIV-infected individuals is unknown. Methodology/Principal Findings:We compared FcRγ expression in peripheral blood mononuclear cells isolated from HIV-1-infected individuals receiving combination antiretroviral therapy and healthy, HIV-1-uninfected individuals. FcRγ mRNA and protein levels were measured using quantitative real-time PCR and immunoblotting, respecti..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council (NHMRC) Grants 358399 and 543137. EL was a recipient of an Australian Postgraduate Award and SMC is of an NHMRC Principal Research Fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.